
One hundred years later, the Predator, now called Scarface, is offered a chance for redemption. Shamed by defeat and having exposed his race to the humans, the Predator is exiled by his clan to a planet inhabited by deadly alien creatures. The predator then sets off his ship's self-destruct sequence but this fails to kill him as he is outside the range of the explosion. As he attempts to reach his ship, the roof he is running across collapses - leaving him incapacitated. The Predator makes a hasty escape, leaving behind some of his equipment. Bruno's wife Isabella shoots the Predator in the eye, causing his blood to splatter on her and her baby son Hunter Borgia. The player controls a Predator who stalks and kills mob boss Bruno Borgia and members of his gang who are at war with the Irish Mob. In first-person mode the player can use vocal mimicry to distract or lure an enemy, while in third-person mode the player can emit a loud roar. The player can also use items, such as medical kits which restore health. Weapon upgrades are found in some of the stages. A number of the weapons reflect those used in the Predator and Alien vs. A variety of weapons are used in the game, falling into the categories of melee and ranged weapons.

The game also has a number of bonus missions in which the player can earn rewards including costumes, weapons, and increased health and energy.
